, 21. Question # 8 (Multiple Choice) Examples of "high-extraction" drugs -- related to hepatic drug clearance: Question # 9 (Multiple Choice) Pharmacogenetic effects: Question # 10 (Multiple Answer) Characteristics of drug conjugates (following conjugation reactions). d) … Question # 3 (Multiple Choice) Hepatic flow-dependent drug elimination refers to: Answer: (B) rate-limiting step is drug delivery to hepatic elimination sites. Distribution of drugs to specific tissues Parenteral administration: a) Cannot be used with unconsciousness patients D) cytochrome P-450. b) Steroid hormone synthesis. d) Thyroid hormone synthesis. The functioning of the liver plays a significant role in the metabolism of drugs. Question # 14 (Multiple Answer) Phase II and reactions: Question # 15 (Multiple Choice) Factors affecting renal clearance of drugs: Question # 16 (Multiple Choice) Concerning drug-plasma protein binding: Question # 17 (Multiple Choice) Mixed function oxidases system is referred to as mediating: Question # 18 (Multiple Answer) Characteristics of drug-protein binding. Home MCQ MCQ TEST (1) PHARMACOLOGY-IV (Clinical Pharmacy and drug interaction) T 4.8.5 MCQ TEST (1) PHARMACOLOGY-IV (Clinical Pharmacy and drug interaction) T 4.8.5 ... A. Which … c) Limiting metabolism. (b) Metabolism of drugs always increases their water solubility (c) Metabolism of drugs always abolishes their pharmacologic activity (d) Hepatic metabolism and renal excretion are the two most important mechanisms involved (e) Distribution of a drug out of the bloodstream terminates the drug’s effect 4. Question # 17 (Multiple Choice) Mixed function oxidases system is referred to as mediating: Question # 18 (Multiple Answer) Characteristics of drug-protein binding, (A) generally theextent of drug-protein binding parallels drug lipids liability, (D) sulfonamides may displace unconjugated bilirubin from albumin-binding sites (because neonatal bilirubin encephalopathy). 1. Match. less than normal therapeutic response to drug therapy ? The pulmonary epithelium as the primary site for metabolism. d) All three drugs have appropriate pharmacodynamic properties as they all achieve maximal physiological effects and have concentrations within the therapeutic window. First pass metabolism is not significant. It has an octanol coefficient of 10 B. glycogen in liver and muscles. c) Limiting metabolism. Learn quiz drug metabolism medicinal chemistry with free interactive flashcards. Answers are entered by clicking the button corresponding to your selection. It has a pKa of 8.4 OP02 [Mar96] Which factor does NOT predispose to bradycardia with fentanyl in doses of 50 mcg/kg? Spell. Question # 1 (Multiple Answer) Factors that could change intrinsic hepatic clearance include: Question # 2 (True/False) In rheumatoid arthritis patients, increased alpha1-acidic glycoprotein may be associated with increased lidocaine protein binding. Question # 9 (Multiple Answer) Drug characteristics contributing to reliable transdermal drug absorption: A) molecular weight less than 1000 (a) Pharmacologic antagonist (b) Partial agonist (c) Physiologic antagonist (d) Chemical antagonist (e) Noncompetitive antagonist 2. c) Drug C has the most appropriate pharmacodynamic properties of the three drugs shown as non-toxic effects are achieved within the therapeutic window. This is a self-grading exam. The enzyme system responsible for the metabolism of most drugs is: A) P-glycoprotein. Question No : 1 The common key product in the inter mediary metabolism is, Question No : 2 Meeting point of all metabolic pathways is, Question No : 3 The process of conversion of harmful ammonia into urea within the liver cells during ornithine cycle is known as, Question No : 4 In mammals, carbohydrates are stored in the form of, Question No : 5 The breaking down of organic compounds and liberation of energy is, Question No : 6 In endotherms the main source of body heat is, Question No : 7 Enzymes, vitamins and hormones can be j classified under one catagory of biological chemicals because all of these, Competitive Exam India | Copyright @2017-2018 | About Us | Contact Us, Hosting partner DigitalOcean - Click here to get $10 joining bonus, DigitalOcean - Click here to get $10 joining bonus. DRUGS OF ABUSE. Created by. Question # 5 (Multiple Choice) Cytochrome P450 induction (increased, amount of P450 enzyme protein) is often associated with: Question # 6 (Multiple Choice) Microsomal drug metabolizing enzymes are typically associated with: Question # 7 (Multiple Answer) Characteristics of drug-protein binding: (A) often parallels drug lipid solubility, (B) drug-plasma albumin binding tends to be relatively nonselective, (D) in rheumatoid arthritis patients, increased alpha1-acidic glycoprotein tends to promote increased lidocaine protein binding. Fentanyl in doses of 50 mcg/kg a predictable and controllable in vivo destruction (.! Doses of 50 mg/kg to a 70 kg man flow is 1500 mls/min, the of! For metabolism choice questions covering drug absorption, biotransformation, transport mcq on drug metabolism excretion are presented...! ) a drug is exposed more prominent liver metabolism d ) … drug metabolism quiz which has attempted! 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